Here is a short list of things I dislike about being on 2 wheels:
1. Lights don't seem to change for me - particularly when in left turn lanes. I wait for another car, then pull past the line, but sometimes that other car never comes, causing a moral dilemma
2. Any "cagers" ever flick a cigarette at you, even if not intentionally?
3. Ahh, the smells, sometimes it is nice to experience aromas you would not notice in a car, but riding 20mps over a rotten skunk carcass is one thing I can do without.
4. While on the subject of roadkill - does anyone get paranoid at night about hitting an animal, alive or otherwise?
Riding is great, but the annoyances are magnified by the vulnerability of being without a protective metal enclosure. Please add to the list if I left out anything.